ABSTRACT The soft rot pathogen Janthinobacterium agaricidamnosum causes devastating damage to button mushrooms (Agaricus bisporus), one of the most cultivated and commercially relevant mushrooms.We previously discovered that this pathogen releases the membrane-disrupting lipopeptide jagaricin.This bacterial toxin, however, could not solely explain
In this study, we estimated the number, length, and frequency of runs of homozygosity (ROH) in 635 Chinese Merino and identified genomic regions with high ROH frequency using the OvineSNP50 whole-genome genotyping array.A total of 6039 ROH exceeding 1 Mb were detected in 634 animals.The average number of ROH in each animal was 9.23 and the average
Abstract Background A model that can predict treatment response for a patient with specific baseline characteristics would help decision-making in personalized medicine.The aim of the study is to develop such a model in the treatment of rheumatoid arthritis (RA) patients who receive certolizumab (CTZ) plus methotrexate (MTX) therapy, using individu
Over 1.2 million people in the United States are infected with the human immunodeficiency virus (HIV).Tremendous progress has been made over the past three decades on many fronts in the prevention and treatment of HIV-1 disease.However, HIV-1 infection is incurable and antiretroviral drugs continue to remain the only effective treatment option for